عنوان: وضعیت پیشرفت دارویی در پیشگیری و درمان پوکی استخوان

نویسندگان:

Peter Schwarz1,Niklas Rye Jørgensen, Bo Abrahamsen

1: Copenhagen University Hospital, Research Centre of Ageing and Osteoporosis, Department of Medicine , Glostrup , Denmark.

 

 

نشریه: Taylor & Francis

 

انتشارات: Informa healthcare

 

تاریخ انتشار: 2014-02-04

 

تاریخ ترجمه: 2014-04-10

 

لینک منابع:

وبسایت مقاله http://www.ncbi.nlm.nih.gov/pubmed

وبسایت نشریه http://www.tandfonline.com

وبسایت انتشارات http://www.informahealthcare.com

 

ترجمه شده توسط تیم تخصصی دُروانا

چکیده:

مقدمه: پوکی استخوان، بیماری متابولیک استخوان، یکی از مشکلات رو به رشدی است که سلامت و اقتصاد را در سر تا سر جهان تحت تاثیر قرار می دهد. بیس فسفونات ها از جمله داروهای پر مصرفی هستند که به عنوان antiresorptive مورد مصرف گسترده ای قرار دارند و در پیشگیری از شکستگی به عنوان استانداردی طلایی به کار می روند و معمولا در ترکیب با مکمل ویتامین D و کلسیم به کار می روند. چندین داروی جدید نیز برای درمان پوکی استخوان بعد از دوران یائسگی در دسترس است.

موارد پوشش داده شده در این مقاله: محققین در این مقاله برخی از آزمون های جدیدی که در ارتباط با antiresorptive و داروهای آنابولیک انجام شده است را ارائه داده اند. به خصوص، دانش فعلی در مورد داروهایی مطرح شده است که علیه cathepsin K و sclerostin تنظیم می شوند. مسیرهای جدید مورد نظر در مطالعات پیش بالینی نیز مورد بحث قرار گرفته است.

لغات کلیدی: cathepsin K، odanacatib ، پوکی استخوان، دوران پس از یائسگی، romosozumab، آنتی بادی مونوکلونال sclerostin-neutralizing، درمان

مقدمه:

استئوپورز یا پوکی استخوان، بیماری متابولیک استخوان است که به عنوان چالشی رو به رشد، سر تاسر جهان را تحت تاثیر قرار داده است. شیوع این بیماری به دلیل افزایش سن جمعیت، بسیار سریع است و در ایالات متحده آمریکا، سالانه 1.5 میلیون شکستگی ناشی از پوکی استخوان در ناحیه ستون فقرات، لگن، ران و مچ اتفاق می افتد. تخمین زده می شود حدود 50% زنان و حدود 25% مردان در سن 50 سالگی و بالای 50 سال، در طول باقی مانده زندگی خود، یک بار شکستگی ناشی از پوکی استخوان را تجربه می کنند (1).

روش ها:

نتایج:

بحث و گفتگو:

دیدگاه تخصصی

بیس فسفونات های خوراکی (آلندرونیت و ریسدرونیت) و در درجه دوم بیس فسفونات های وریدی(زولدرونیک اسید) از جمله فراوان ترین داروهایی هستند که در درمان پوکی استخوان به کار می روند زیرا هم هزینه پایینی دارند و هم نتایج موثری را در کاهش ریسک شکستگی نشان داده اند.

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